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Endocrine Abstracts

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ea0090rc7.1 | Rapid Communications 7: Pituitary and Neuroendocrinology 2 | ECE2023

Splicing factor 3B subunit 1 (SF3B1) role in PRL-secreting PitNETs

Mangili Federica , Muro Genesio Di , Arlati Federico , Barbieri Anna Maria , E. G-Garcia Miguel , Esposito Emanuela , Treppiedi Donatella , Catalano Rosa , Marra Giusy , Nozza E mma , Locatelli Marco , Lania Andrea , Ferrante Emanuele , Sala Elisa , P. Castano Justo , M. Luque Raul , Arosio Maura , Peverelli Erika , Mantovani Giovanna

Dopamine receptor type 2 (DRD2) represents the main target for pharmacological therapy with dopamine agonists (DAs) in PRL-secreting neuroendocrine pituitary tumors (PRL-PitNET), even if about 10% of patients is resistant. A single paper recently described a somatic mutation in the gene encoding splicing factor 3B subunit 1 (SF3B1) in about 20% of patients with PRL-PitNET, that was associated with PRL hypersecretion, increased cell proliferation and invasion and reduced progre...
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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